Dopamine D3 receptors modulate the rate of neuronal recovery, cell recruitment in Area X, and song tempo after neurotoxic damage in songbirds

Highlights • Activation of D3Rs reduces lesion size within the striatal vocal nucleus Area X after injury. • Activation of D3Rs increases the number of young neurons in Area X after injury. • Striatal injury increases the mRNA expression of D3Rs in the neurogenic subventricular zone and in RA. • The...

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Veröffentlicht in:	Neuroscience 2016-09, Vol.331, p.158-168
Hauptverfasser:	Lukacova, Kristina, Pavukova, Eva, Kostal, Lubor, Bilcik, Boris, Kubikova, Lubica
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Proteins - agonists Avian Proteins - antagonists & inhibitors Avian Proteins - metabolism brain injury Cell Movement - drug effects Cell Movement - physiology Corpus Striatum - drug effects Corpus Striatum - injuries Corpus Striatum - metabolism Corpus Striatum - pathology Disease Models, Animal Dopamine Agents - pharmacology dopamine D3 receptors Finches - physiology Ibotenic Acid Indans - pharmacology Male Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurogenesis - drug effects Neurogenesis - physiology Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - drug effects Neurons - metabolism Neurons - pathology Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - metabolism Recovery of Function - drug effects Recovery of Function - physiology RNA, Messenger - metabolism song tempo Stem Cell Niche - drug effects Stem Cell Niche - physiology striatum Taeniopygia guttata Tetrahydronaphthalenes - pharmacology Vocalization, Animal - drug effects Vocalization, Animal - physiology zebra finch
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Zusammenfassung:	Highlights • Activation of D3Rs reduces lesion size within the striatal vocal nucleus Area X after injury. • Activation of D3Rs increases the number of young neurons in Area X after injury. • Striatal injury increases the mRNA expression of D3Rs in the neurogenic subventricular zone and in RA. • The lesion-induced changes in song tempo may be facilitated by D3Rs in the motor nucleus RA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.06.032