Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease
Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-pos...
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| Veröffentlicht in: | Neuroscience 2016-08, Vol.330, p.236-246 |
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| container_title | Neuroscience |
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| creator | Liu, Lei Watanabe, Naoki Akatsu, Hiroyasu Nishimura, Masaki |
| description | Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-positive neurons decreases in brains with Alzheimer’s disease. |
| doi_str_mv | 10.1016/j.neuroscience.2016.05.050 |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-fe7c041404f8d96771374d6c5b79ccb0a79753e41d4de6a6ba8345f069f2f1063</citedby><cites>FETCH-LOGICAL-c534t-fe7c041404f8d96771374d6c5b79ccb0a79753e41d4de6a6ba8345f069f2f1063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2016.05.050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27256505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Watanabe, Naoki</creatorcontrib><creatorcontrib>Akatsu, Hiroyasu</creatorcontrib><creatorcontrib>Nishimura, Masaki</creatorcontrib><title>Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-positive neurons decreases in brains with Alzheimer’s disease.</description><subject>age</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer’s disease</subject><subject>amyloid-β</subject><subject>Animals</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>FAM3C</subject><subject>Female</subject><subject>Gene Knockout Techniques</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>ILEI</subject><subject>Immunohistochemistry</subject><subject>Immunoprecipitation</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>γ-secretase</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9uEzEQxi1ERdPCK6AVJy6bjv_vckCKQlsiBTjQni3HnhUOm91g71aUE6_B6_EkeJUUIU61RrLk-eYb-TdDyCsKcwpUXWznHY6xTy5g53DO8tscZA54Qma00rzUUoinZAYcVCkkY6fkLKUt5CMFf0ZOmWZSSZAzsv44WXW2LfD7PmJKoe-KvilW68vVxdXiA18WtvNFGFIR0Y9umPKhKxbtjy8Ydhh___yVCh8S2oTPyUlj24Qvjvc5ub26vFm-L9efrlfLxbp0kouhbFA7EFSAaCpfK60p18IrJze6dm4DVtdachTUC4_Kqo2tuJANqLphDQXFz8nrg-8-9t9GTIPZheSwbW2H_ZgMraBStaCaPUYKGihnOkvfHKQus00RG7OPYWfjvaFgJvBma_4FbybwBmQOyMUvj33GzQ7939IH0lnw7iDADOYuYDRHGx8iusH4Pjyuz9v_bFwbuuBs-xXvMW37MeZh5n-ZxAyYz9MKTBtAFQcGNed_AAkLrwI</recordid><startdate>20160825</startdate><enddate>20160825</enddate><creator>Liu, Lei</creator><creator>Watanabe, Naoki</creator><creator>Akatsu, Hiroyasu</creator><creator>Nishimura, Masaki</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160825</creationdate><title>Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease</title><author>Liu, Lei ; Watanabe, Naoki ; Akatsu, Hiroyasu ; Nishimura, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-fe7c041404f8d96771374d6c5b79ccb0a79753e41d4de6a6ba8345f069f2f1063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>age</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer’s disease</topic><topic>amyloid-β</topic><topic>Animals</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>FAM3C</topic><topic>Female</topic><topic>Gene Knockout Techniques</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>ILEI</topic><topic>Immunohistochemistry</topic><topic>Immunoprecipitation</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>γ-secretase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Watanabe, Naoki</creatorcontrib><creatorcontrib>Akatsu, Hiroyasu</creatorcontrib><creatorcontrib>Nishimura, Masaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lei</au><au>Watanabe, Naoki</au><au>Akatsu, Hiroyasu</au><au>Nishimura, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-08-25</date><risdate>2016</risdate><volume>330</volume><spage>236</spage><epage>246</epage><pages>236-246</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-positive neurons decreases in brains with Alzheimer’s disease.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27256505</pmid><doi>10.1016/j.neuroscience.2016.05.050</doi><tpages>11</tpages></addata></record> |
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| subjects | age Aged, 80 and over Aging - metabolism Aging - pathology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer’s disease amyloid-β Animals Brain - growth & development Brain - metabolism Brain - pathology Cytokines - genetics Cytokines - metabolism FAM3C Female Gene Knockout Techniques HEK293 Cells Humans ILEI Immunohistochemistry Immunoprecipitation Male Mice, Inbred C57BL Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neurology Neurons - metabolism Neurons - pathology γ-secretase |
| title | Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease |
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