Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease

Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-pos...

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Veröffentlicht in:	Neuroscience 2016-08, Vol.330, p.236-246
Hauptverfasser:	Liu, Lei, Watanabe, Naoki, Akatsu, Hiroyasu, Nishimura, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	age Aged, 80 and over Aging - metabolism Aging - pathology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer’s disease amyloid-β Animals Brain - growth & development Brain - metabolism Brain - pathology Cytokines - genetics Cytokines - metabolism FAM3C Female Gene Knockout Techniques HEK293 Cells Humans ILEI Immunohistochemistry Immunoprecipitation Male Mice, Inbred C57BL Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neurology Neurons - metabolism Neurons - pathology γ-secretase
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Zusammenfassung:	Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active zone-docked synaptic vesicles. • ILEI expression levels in brain peaks during the postnatal period and declines with age. • The number of ILEI-positive neurons decreases in brains with Alzheimer’s disease.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.05.050