HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage

Highlights • Higher incidence of HLA antibodies in women with recurrent miscarriage. • The increased HLA-C antibodies is relevant for the local situation in the placenta. • The majority of HLA-C antibodies in recurrent miscarriage were complement fixing.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of reproductive immunology 2016-08, Vol.116, p.28-34
Hauptverfasser:	Meuleman, T, can Beelen, E, Kaaja, R.J, van Lith, J.M.M, Claas, F.H.J, Bloemenkamp, K.W.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - immunology Adult Antibodies - metabolism Antibody-Dependent Cell Cytotoxicity Case-Control Studies Complement Activation Complement C4b - metabolism Female HLA antibodies HLA-C Antigens - immunology HLA-C Antigens - metabolism Humans Humoral rejection Immunology Obstetrics and Gynecology Peptide Fragments - metabolism Pregnancy Pregnancy Trimester, First Protein Binding Recurrent miscarriage Trophoblasts - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Higher incidence of HLA antibodies in women with recurrent miscarriage. • The increased HLA-C antibodies is relevant for the local situation in the placenta. • The majority of HLA-C antibodies in recurrent miscarriage were complement fixing.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2016.03.003