Leaf extracts from Teucrium ramosissimum protect against DNA damage in human lymphoblast cell K562 and enhance antioxidant, antigenotoxic and antiproliferative activity
Highlights • Antioxidant, antigenotoxic and antiproliferative effects of T. ramosissimum extracts were investigated. • All extracts enhanced antioxidant activity. • T. ramosissimum extracts were effective in protecting plasmid DNA against the strand breakage. • Methanol extract inhibited the prolife...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2016-06, Vol.44, p.44-52 |
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| container_title | Environmental toxicology and pharmacology |
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| creator | Sghaier, Mohamed Ben Ismail, Manel Ben Bouhlel, Ines Ghedira, Kamel Chekir-Ghedira, Leila |
| description | Highlights • Antioxidant, antigenotoxic and antiproliferative effects of T. ramosissimum extracts were investigated. • All extracts enhanced antioxidant activity. • T. ramosissimum extracts were effective in protecting plasmid DNA against the strand breakage. • Methanol extract inhibited the proliferation of K562. • It also inhibited the genotoxicity induced by H2 O2. |
| doi_str_mv | 10.1016/j.etap.2016.04.006 |
| format | Article |
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| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2016-06, Vol.44, p.44-52 |
| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antigenotoxic activity Antimutagenic Agents - chemistry Antimutagenic Agents - pharmacology Antioxidant capacity Antioxidants - chemistry Antioxidants - pharmacology Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Comet Assay Comet assay. Teucrium ramosissimum DNA Damage - drug effects Emergency Flavonoids - analysis Humans Hydrogen Peroxide - toxicity K562 Cells Lymphocytes - drug effects Lymphocytes - metabolism Mutagens - toxicity Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves Polyphenols - analysis Teucrium Teucrium - chemistry |
| title | Leaf extracts from Teucrium ramosissimum protect against DNA damage in human lymphoblast cell K562 and enhance antioxidant, antigenotoxic and antiproliferative activity |
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