Leaf extracts from Teucrium ramosissimum protect against DNA damage in human lymphoblast cell K562 and enhance antioxidant, antigenotoxic and antiproliferative activity

Highlights • Antioxidant, antigenotoxic and antiproliferative effects of T. ramosissimum extracts were investigated. • All extracts enhanced antioxidant activity. • T. ramosissimum extracts were effective in protecting plasmid DNA against the strand breakage. • Methanol extract inhibited the prolife...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-06, Vol.44, p.44-52
Hauptverfasser:	Sghaier, Mohamed Ben, Ismail, Manel Ben, Bouhlel, Ines, Ghedira, Kamel, Chekir-Ghedira, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigenotoxic activity Antimutagenic Agents - chemistry Antimutagenic Agents - pharmacology Antioxidant capacity Antioxidants - chemistry Antioxidants - pharmacology Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Comet Assay Comet assay. Teucrium ramosissimum DNA Damage - drug effects Emergency Flavonoids - analysis Humans Hydrogen Peroxide - toxicity K562 Cells Lymphocytes - drug effects Lymphocytes - metabolism Mutagens - toxicity Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves Polyphenols - analysis Teucrium Teucrium - chemistry
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Zusammenfassung:	Highlights • Antioxidant, antigenotoxic and antiproliferative effects of T. ramosissimum extracts were investigated. • All extracts enhanced antioxidant activity. • T. ramosissimum extracts were effective in protecting plasmid DNA against the strand breakage. • Methanol extract inhibited the proliferation of K562. • It also inhibited the genotoxicity induced by H2 O2.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.04.006