Generation of sensory hair cells by genetic programming with a combination of transcription factors

© 2015. Published by The Company of Biologists Ltd. Mechanosensory hair cells (HCs) are the primary receptors of our senses of hearing and balance. Elucidation of the transcriptional networks regulating HC fate determination and differentiation is crucial not only to understand inner ear development...

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Veröffentlicht in:	Development (Cambridge) 2015-06, Vol.142 (11), p.1948-1959
Hauptverfasser:	Costa, Aida, Sanchez-Guardado, Luis, Juniat, Stephanie, Gale, Jonathan E., Daudet, Nicolas, Pinto Henrique, Domingos Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atoh1 Cell Differentiation - drug effects Cell Differentiation - genetics Cell Lineage - drug effects Cell Lineage - genetics Cell Shape - drug effects Cell type programming Cellular Reprogramming - drug effects Chick Embryo Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - ultrastructure Fluorescence Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Gene regulation Genes, Reporter Gfi1 Hair cells Hair Cells, Auditory - cytology Hair Cells, Auditory - drug effects Hair Cells, Auditory - metabolism Mice Receptors, Notch - metabolism Signal Transduction - drug effects Signal Transduction - genetics Transcription Factors - metabolism Transcriptome - genetics Tretinoin - pharmacology
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