Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia–reperfusion injury

Highlights • MST1 is involved in microglial activation induced by brain ischemic stroke. • Src acts as the upstream of MST1 in microglial activation. • MST1 regulates inflammatory factors release through NF-κB pathway. • Loss of MST1 in microglia/macrophage protects cerebral ischemia-induced brain i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.236-248
Hauptverfasser:	Zhao, Siqi, Yin, Jie, Zhou, Lujun, Yan, Feng, He, Qing, Huang, Li, Peng, Shengyi, Jia, Junying, Cheng, Jinbo, Chen, Hong, Tao, Wufan, Ji, Xunming, Xu, Yun, Yuan, Zengqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Hippo/MST1 Ischemia IκB Mice Mice, Inbred C57BL Microglia Microglia - immunology NF-kappa B - metabolism Protein-Serine-Threonine Kinases - metabolism Psychiatry Reperfusion Injury - immunology Signal Transduction - immunology Src src-Family Kinases - metabolism
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Zusammenfassung:	Highlights • MST1 is involved in microglial activation induced by brain ischemic stroke. • Src acts as the upstream of MST1 in microglial activation. • MST1 regulates inflammatory factors release through NF-κB pathway. • Loss of MST1 in microglia/macrophage protects cerebral ischemia-induced brain injury.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.12.016