Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer

Highlights • Nampt is overexpressed in pancreatic cancer. • Inhibition of Nampt impaired pancreatic cancer growth in vitro and in vivo. • The expression of Nampt is regulated by miR-206 in pancreatic cancer. • Inhibition of Nampt enhanced the antitumor activity of gemcitabine in PDAC.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-08, Vol.379 (1), p.1-11
Hauptverfasser:	Ju, Huai-Qiang, Zhuang, Zhuo-Nan, Li, Hao, Tian, Tian, Lu, Yun-Xin, Fan, Xiao-Qiang, Zhou, Hai-Jun, Mo, Hai-Yu, Sheng, Hui, Chiao, Paul J, Xu, Rui-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Acrylamides - pharmacology Aerobic glycolysis Animals Antimetabolites, Antineoplastic - pharmacology Binding Sites Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - enzymology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cloning Cytokines - antagonists & inhibitors Cytokines - genetics Cytokines - metabolism Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxyribonucleic acid DNA DNA repair Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Enzyme Inhibitors - pharmacology Enzymes Female Glycolysis - drug effects Hematology, Oncology and Palliative Medicine Humans Hypotheses Laboratory animals Metabolism Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID MicroRNAs - genetics MicroRNAs - metabolism miR-206 NAD NAD - metabolism Nampt Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Nicotinamide Phosphoribosyltransferase - genetics Nicotinamide Phosphoribosyltransferase - metabolism Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Piperidines - pharmacology R&D Regulation Research & development RNA Interference Salvage Studies Time Factors Transfection Tumor Burden - drug effects Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Highlights • Nampt is overexpressed in pancreatic cancer. • Inhibition of Nampt impaired pancreatic cancer growth in vitro and in vivo. • The expression of Nampt is regulated by miR-206 in pancreatic cancer. • Inhibition of Nampt enhanced the antitumor activity of gemcitabine in PDAC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.05.024