Microglia activation is associated with IFN-α induced depressive-like behavior
Highlights • IFN-α induces depressive-like behavior in mice. • IFN-α enhances the expression of MHC-II, CD86, and CD54 in the microglia. • MHC-II and CD86 expression is specifically associated with depressive-like behavior.
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.105-113 |
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| container_end_page | 113 |
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| container_start_page | 105 |
| container_title | Brain, behavior, and immunity |
| container_volume | 55 |
| creator | Wachholz, Simone Eßlinger, Manuela Plümper, Jennifer Manitz, Marie-Pierre Juckel, Georg Friebe, Astrid |
| description | Highlights • IFN-α induces depressive-like behavior in mice. • IFN-α enhances the expression of MHC-II, CD86, and CD54 in the microglia. • MHC-II and CD86 expression is specifically associated with depressive-like behavior. |
| doi_str_mv | 10.1016/j.bbi.2015.09.016 |
| format | Article |
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| identifier | ISSN: 0889-1591 |
| ispartof | Brain, behavior, and immunity, 2016-07, Vol.55, p.105-113 |
| issn | 0889-1591 1090-2139 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Behavior, Animal - physiology CD54 CD86 Depression Depression - chemically induced Depression - immunology Depression - physiopathology Depressive-like behavior Disease Models, Animal Immunologic Factors - administration & dosage Immunologic Factors - pharmacology Interferon-alpha Interferon-alpha - administration & dosage Interferon-alpha - pharmacokinetics Male MHC-II Mice Mice, Inbred BALB C Microglia Microglia - immunology Psychiatry |
| title | Microglia activation is associated with IFN-α induced depressive-like behavior |
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