Activation of corticotropin-releasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats

Highlights • Role of microglia and CRF neurons in PVN on visceral hypersensitivity is unclear. • Inhibition of PVN CRF neurons suppresses visceral hypersensitivity in rats. • Visceral hypersensitivity is related to microglial and TLR4 signaling hyperactivity. • Microglial inhibition suppresses CRF n...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.93-104
Hauptverfasser:	Zhang, Gongliang, Yu, Le, Chen, Zi-Yang, Zhu, Jun-Sheng, Hua, Rong, Qin, Xia, Cao, Jun-Li, Zhang, Yong-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Colon - physiopathology Corticotropin-Releasing Hormone - metabolism Disease Models, Animal Irritable bowel syndrome Irritable Bowel Syndrome - metabolism Male Microglia Microglia - metabolism Neurons - metabolism Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Psychiatry Rats Rats, Sprague-Dawley Rectum - physiopathology Toll-like receptor 4 Toll-Like Receptor 4 - metabolism Visceral hypersensitivity Visceral Pain - metabolism
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Zusammenfassung:	Highlights • Role of microglia and CRF neurons in PVN on visceral hypersensitivity is unclear. • Inhibition of PVN CRF neurons suppresses visceral hypersensitivity in rats. • Visceral hypersensitivity is related to microglial and TLR4 signaling hyperactivity. • Microglial inhibition suppresses CRF neuronal and visceral hypersensitivity.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.12.022