Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population
Objectives Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an...
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| Veröffentlicht in: | American journal of human biology 2016-07, Vol.28 (4), p.580-583 |
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| creator | Streeter, Elizabeth A. Squires, Erica C. Leonard, William R. Tarskaia, Larissa A. Klimova, Tatiana M. Fedorova, Valentina I. Baltakhinova, Marina E. Krivoshapkin, Vadim G. Snodgrass, J. Josh |
| description | Objectives
Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an adipocyte‐derived hormone with anti‐inflammatory properties) are inversely correlated with hemoglobin levels in an indigenous Siberian population.
Methods
The study was conducted among 252 Yakut adults (≥18 years; 135 females) from Berdygestiakh, Sakha Republic, Russia. Measurements included anthropometric dimensions (body mass index [BMI], waist circumference [WC], and percent body fat) and blood levels of hemoglobin and adiponectin.
Results
Yakut females had higher adiponectin concentrations than males (15.1 ± 9.8 vs. 11.7 ± 10.6 µg/ml; P < 0.001), whereas males had higher hemoglobin levels (14.4 ± 1.4 vs. 12.6 ± 1.5 g/dL; P |
| doi_str_mv | 10.1002/ajhb.22808 |
| format | Article |
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Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an adipocyte‐derived hormone with anti‐inflammatory properties) are inversely correlated with hemoglobin levels in an indigenous Siberian population.
Methods
The study was conducted among 252 Yakut adults (≥18 years; 135 females) from Berdygestiakh, Sakha Republic, Russia. Measurements included anthropometric dimensions (body mass index [BMI], waist circumference [WC], and percent body fat) and blood levels of hemoglobin and adiponectin.
Results
Yakut females had higher adiponectin concentrations than males (15.1 ± 9.8 vs. 11.7 ± 10.6 µg/ml; P < 0.001), whereas males had higher hemoglobin levels (14.4 ± 1.4 vs. 12.6 ± 1.5 g/dL; P < 0.001). Body composition measures in both sexes were negatively associated with adiponectin and positively associated with hemoglobin. After adjusting for central adiposity and smoking, adiponectin levels were negatively correlated with hemoglobin levels in men (P < 0.05), but not in women (P = 0.511).
Conclusions
This investigation provides some support for the involvement of hypoxia‐related dysregulation of adiponectin associated with obesity and potentially cardiovascular disease. Am. J. Hum. Biol. 28:580–583, 2016. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 1042-0533</identifier><identifier>EISSN: 1520-6300</identifier><identifier>DOI: 10.1002/ajhb.22808</identifier><identifier>PMID: 26593323</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adiponectin - blood ; Adult ; Aged ; Body Composition ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - etiology ; Female ; Hemoglobin ; Hemoglobins - metabolism ; Humans ; Hypoxia ; Male ; Metabolic disorders ; Middle Aged ; Obesity - blood ; Obesity - epidemiology ; Obesity - ethnology ; Obesity - etiology ; Risk Factors ; Siberia - epidemiology ; Siberia - ethnology ; Young Adult</subject><ispartof>American journal of human biology, 2016-07, Vol.28 (4), p.580-583</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5688-1a50a5170a563940d72d259a943777bf8bb3f5c75697a70b42fd53375e60544b3</citedby><cites>FETCH-LOGICAL-c5688-1a50a5170a563940d72d259a943777bf8bb3f5c75697a70b42fd53375e60544b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajhb.22808$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajhb.22808$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26593323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Streeter, Elizabeth A.</creatorcontrib><creatorcontrib>Squires, Erica C.</creatorcontrib><creatorcontrib>Leonard, William R.</creatorcontrib><creatorcontrib>Tarskaia, Larissa A.</creatorcontrib><creatorcontrib>Klimova, Tatiana M.</creatorcontrib><creatorcontrib>Fedorova, Valentina I.</creatorcontrib><creatorcontrib>Baltakhinova, Marina E.</creatorcontrib><creatorcontrib>Krivoshapkin, Vadim G.</creatorcontrib><creatorcontrib>Snodgrass, J. Josh</creatorcontrib><title>Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population</title><title>American journal of human biology</title><addtitle>Am. J. Hum. Biol</addtitle><description>Objectives
Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an adipocyte‐derived hormone with anti‐inflammatory properties) are inversely correlated with hemoglobin levels in an indigenous Siberian population.
Methods
The study was conducted among 252 Yakut adults (≥18 years; 135 females) from Berdygestiakh, Sakha Republic, Russia. Measurements included anthropometric dimensions (body mass index [BMI], waist circumference [WC], and percent body fat) and blood levels of hemoglobin and adiponectin.
Results
Yakut females had higher adiponectin concentrations than males (15.1 ± 9.8 vs. 11.7 ± 10.6 µg/ml; P < 0.001), whereas males had higher hemoglobin levels (14.4 ± 1.4 vs. 12.6 ± 1.5 g/dL; P < 0.001). Body composition measures in both sexes were negatively associated with adiponectin and positively associated with hemoglobin. After adjusting for central adiposity and smoking, adiponectin levels were negatively correlated with hemoglobin levels in men (P < 0.05), but not in women (P = 0.511).
Conclusions
This investigation provides some support for the involvement of hypoxia‐related dysregulation of adiponectin associated with obesity and potentially cardiovascular disease. Am. J. Hum. Biol. 28:580–583, 2016. © 2015 Wiley Periodicals, Inc.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Body Composition</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>Obesity - ethnology</subject><subject>Obesity - etiology</subject><subject>Risk Factors</subject><subject>Siberia - epidemiology</subject><subject>Siberia - ethnology</subject><subject>Young Adult</subject><issn>1042-0533</issn><issn>1520-6300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvGyEUhVHVqEncbvoDqpG6qaJMeoEBhqWbt2W1m0b1DsEME2OPhwl48vj3wXGSRRZVNpcr-O4R9xyEvmI4wgDkp17MzREhJZQf0B5mBHJOAT6mHgqSA6N0F-3HuAAAyaH8hHYJZ5JSQvfQ1bh2ve9stXbdYTa3K3_derPpdVdnlQ6187c6VkOrQxZcXGauS0-p1u7adn6IWXTGBpfuet8nbO189xntNLqN9svzOUJXZ6d_jy_y6Z_zy-PxNK8YL8scawaaYZEKp7KAWpCaMKllQYUQpimNoQ2rBONSaAGmIE2dthHMcmBFYegI_djq9sHfDDau1crFyrat7mz6msLJEy6kYPg9aFEyKZMxI_T9DbrwQ-jSIk8UkKIkJFEHW6oKPsZgG9UHt9LhQWFQm1zUJhf1lEuCvz1LDmZl61f0JYgE4C1w51r78B8pNZ5c_HoRzbczLq7t_euMDkvFRXJJ_ft9rjidncwomaoJfQQ-HqSv</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Streeter, Elizabeth A.</creator><creator>Squires, Erica C.</creator><creator>Leonard, William R.</creator><creator>Tarskaia, Larissa A.</creator><creator>Klimova, Tatiana M.</creator><creator>Fedorova, Valentina I.</creator><creator>Baltakhinova, Marina E.</creator><creator>Krivoshapkin, Vadim G.</creator><creator>Snodgrass, J. Josh</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7SN</scope><scope>7ST</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population</title><author>Streeter, Elizabeth A. ; Squires, Erica C. ; Leonard, William R. ; Tarskaia, Larissa A. ; Klimova, Tatiana M. ; Fedorova, Valentina I. ; Baltakhinova, Marina E. ; Krivoshapkin, Vadim G. ; Snodgrass, J. Josh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5688-1a50a5170a563940d72d259a943777bf8bb3f5c75697a70b42fd53375e60544b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Body Composition</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>Obesity - ethnology</topic><topic>Obesity - etiology</topic><topic>Risk Factors</topic><topic>Siberia - epidemiology</topic><topic>Siberia - ethnology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Streeter, Elizabeth A.</creatorcontrib><creatorcontrib>Squires, Erica C.</creatorcontrib><creatorcontrib>Leonard, William R.</creatorcontrib><creatorcontrib>Tarskaia, Larissa A.</creatorcontrib><creatorcontrib>Klimova, Tatiana M.</creatorcontrib><creatorcontrib>Fedorova, Valentina I.</creatorcontrib><creatorcontrib>Baltakhinova, Marina E.</creatorcontrib><creatorcontrib>Krivoshapkin, Vadim G.</creatorcontrib><creatorcontrib>Snodgrass, J. Josh</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ecology Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of human biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Streeter, Elizabeth A.</au><au>Squires, Erica C.</au><au>Leonard, William R.</au><au>Tarskaia, Larissa A.</au><au>Klimova, Tatiana M.</au><au>Fedorova, Valentina I.</au><au>Baltakhinova, Marina E.</au><au>Krivoshapkin, Vadim G.</au><au>Snodgrass, J. Josh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population</atitle><jtitle>American journal of human biology</jtitle><addtitle>Am. J. Hum. Biol</addtitle><date>2016-07</date><risdate>2016</risdate><volume>28</volume><issue>4</issue><spage>580</spage><epage>583</epage><pages>580-583</pages><issn>1042-0533</issn><eissn>1520-6300</eissn><abstract>Objectives
Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an adipocyte‐derived hormone with anti‐inflammatory properties) are inversely correlated with hemoglobin levels in an indigenous Siberian population.
Methods
The study was conducted among 252 Yakut adults (≥18 years; 135 females) from Berdygestiakh, Sakha Republic, Russia. Measurements included anthropometric dimensions (body mass index [BMI], waist circumference [WC], and percent body fat) and blood levels of hemoglobin and adiponectin.
Results
Yakut females had higher adiponectin concentrations than males (15.1 ± 9.8 vs. 11.7 ± 10.6 µg/ml; P < 0.001), whereas males had higher hemoglobin levels (14.4 ± 1.4 vs. 12.6 ± 1.5 g/dL; P < 0.001). Body composition measures in both sexes were negatively associated with adiponectin and positively associated with hemoglobin. After adjusting for central adiposity and smoking, adiponectin levels were negatively correlated with hemoglobin levels in men (P < 0.05), but not in women (P = 0.511).
Conclusions
This investigation provides some support for the involvement of hypoxia‐related dysregulation of adiponectin associated with obesity and potentially cardiovascular disease. Am. J. Hum. Biol. 28:580–583, 2016. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26593323</pmid><doi>10.1002/ajhb.22808</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of human biology, 2016-07, Vol.28 (4), p.580-583 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adiponectin - blood Adult Aged Body Composition Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - ethnology Cardiovascular Diseases - etiology Female Hemoglobin Hemoglobins - metabolism Humans Hypoxia Male Metabolic disorders Middle Aged Obesity - blood Obesity - epidemiology Obesity - ethnology Obesity - etiology Risk Factors Siberia - epidemiology Siberia - ethnology Young Adult |
| title | Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population |
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