Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population

Objectives Adipose tissue hypoxia appears to play a role in promoting chronic inflammation and the development of obesity‐related cardiovascular and metabolic diseases, yet the underlying mechanisms are not well understood. The aim of the present research is to examine whether adiponectin levels (an adipocyte‐derived hormone with anti‐inflammatory properties) are inversely correlated with hemoglobin levels in an indigenous Siberian population. Methods The study was conducted among 252 Yakut adults (≥18 years; 135 females) from Berdygestiakh, Sakha Republic, Russia. Measurements included anthropometric dimensions (body mass index [BMI], waist circumference [WC], and percent body fat) and blood levels of hemoglobin and adiponectin. Results Yakut females had higher adiponectin concentrations than males (15.1 ± 9.8 vs. 11.7 ± 10.6 µg/ml; P < 0.001), whereas males had higher hemoglobin levels (14.4 ± 1.4 vs. 12.6 ± 1.5 g/dL; P