Silencing of CtBP1 suppresses the migration in human glioma cells

Carboxyl-terminal binding protein 1 (CtBP1), up-regulated in various types of human cancers, has been functionally associated with proliferation, anti-apoptosis, and EMT in vitro studies. However, the functional significance of CtBP1 in the pathophysiology of glioma remains unknown. In the present s...

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Veröffentlicht in:	Journal of molecular histology 2016-06, Vol.47 (3), p.297-304
Hauptverfasser:	Zhao, Chengjin, Shen, Yifen, Tao, Xuelei, Xu, Jian, Lu, Junjie, Liu, Chao, Xu, Zhiwei, Tang, Qing, Tao, Tao, Zhang, Xiubing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alcohol Oxidoreductases - genetics Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell Movement - genetics Cell Proliferation Developmental Biology DNA-Binding Proteins - genetics Female Gene Expression Gene Silencing Glioma - genetics Glioma - mortality Glioma - pathology Glioma - therapy Humans Kaplan-Meier Estimate Life Sciences Male Middle Aged Neoplasm Grading Neoplasm Staging Original Paper Prognosis
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Zusammenfassung:	Carboxyl-terminal binding protein 1 (CtBP1), up-regulated in various types of human cancers, has been functionally associated with proliferation, anti-apoptosis, and EMT in vitro studies. However, the functional significance of CtBP1 in the pathophysiology of glioma remains unknown. In the present study, we showed the expression of CtBP1 was markedly higher in glioma tissues compared with normal brain tissues by Western blot analysis. Immunohistochemical analysis revealed that CtBP1 mainly localized in the nucleus of glioma cells. Statistical analysis suggested the upregulation of CtBP1 was considerably correlated with the WHO grade ( P
ISSN:	1567-2379 1567-2387
DOI:	10.1007/s10735-016-9678-z