A novel HLA-B allele, HLA-B35:279, identified by sequencing-based typing in a Czech patient

A novel HLA-B allele, HLA-B35:279, identified by sequencing-based typing in a Czech patient

Summary The identification of a novel HLA‐B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA‐B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 doma...

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Veröffentlicht in:International journal of immunogenetics 2016-08, Vol.43 (4), p.246-248
Hauptverfasser: Mrazek, F., Onderkova, J., Königova, N., Siffnerova, V., Vrana, M., Ambruzova, Z., Skoumalova, I., Petrek, M., Raida, L.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Amino Acid Substitution
Base Sequence
Czech Republic
Histocompatibility Testing
HLA-B Antigens - genetics
HLA-B Antigens - immunology
HLA-B Antigens - isolation & purification
Humans
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Beschreibung
Zusammenfassung:Summary The identification of a novel HLA‐B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA‐B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA‐B antigen.
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12276