Morphology of primary cilia in pancreatic duct of the polycystic kidney rat

To study the role of primary cilia in pancreatic duct, We have previously demonstrated that (1) pancreatic ducts of PCK (-/-) rat were dilated and elongated, that (2) secretin-stimulated fluid secretion from isolated interlobular pancreatic ducts of the PCK rat was augmented compared with that from ducts of the wild type (+/+), and that (3) reciprocal flow-dependent purinergic Ca2+ signaling in pancreatic ducts isolated from PCK rats, which were microperfused from the proximal end (acinar side) or from the distal end (duodenal side).