Neutralizing and ELISA IgG antibodies to human cytomegalovirus glycoprotein complexes may help date the onset of primary infection in pregnancy
Highlights • Conventional assays for HCMV IgG, IgM and avidity help date primary infection onset. • Novel ELISA IgG to different HCMV glycoproteins contribute to date infection onset. • Both conventional and novel assays define an algorithm crucial for infection timing.
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| Veröffentlicht in: | Journal of clinical virology 2016-08, Vol.81, p.16-24 |
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| container_title | Journal of clinical virology |
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| creator | Lilleri, D Gerna, G Furione, M Zavattoni, M Spinillo, A |
| description | Highlights • Conventional assays for HCMV IgG, IgM and avidity help date primary infection onset. • Novel ELISA IgG to different HCMV glycoproteins contribute to date infection onset. • Both conventional and novel assays define an algorithm crucial for infection timing. |
| doi_str_mv | 10.1016/j.jcv.2016.05.007 |
| format | Article |
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| issn | 1386-6532 1873-5967 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Cytomegalovirus - immunology Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology ELISA IgG assays Female Glycoproteins - immunology HCMV glycoprotein complexes HCMV primary infection onset Human cytomegalovirus Humans Immunoglobulin G - blood Infectious Disease Neutralization assays Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - virology Retrospective Studies Serological assays Viral Envelope Proteins - immunology |
| title | Neutralizing and ELISA IgG antibodies to human cytomegalovirus glycoprotein complexes may help date the onset of primary infection in pregnancy |
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