Neutralizing and ELISA IgG antibodies to human cytomegalovirus glycoprotein complexes may help date the onset of primary infection in pregnancy

Highlights • Conventional assays for HCMV IgG, IgM and avidity help date primary infection onset. • Novel ELISA IgG to different HCMV glycoproteins contribute to date infection onset. • Both conventional and novel assays define an algorithm crucial for infection timing.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical virology 2016-08, Vol.81, p.16-24
Hauptverfasser:	Lilleri, D, Gerna, G, Furione, M, Zavattoni, M, Spinillo, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Cytomegalovirus - immunology Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology ELISA IgG assays Female Glycoproteins - immunology HCMV glycoprotein complexes HCMV primary infection onset Human cytomegalovirus Humans Immunoglobulin G - blood Infectious Disease Neutralization assays Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - virology Retrospective Studies Serological assays Viral Envelope Proteins - immunology
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Beschreibung
Zusammenfassung:	Highlights • Conventional assays for HCMV IgG, IgM and avidity help date primary infection onset. • Novel ELISA IgG to different HCMV glycoproteins contribute to date infection onset. • Both conventional and novel assays define an algorithm crucial for infection timing.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2016.05.007