Toxic Epidermal Necrolysis-like Reaction With Severe Satellite Cell Necrosis Associated With Nivolumab in a Patient With Ipilimumab Refractory Metastatic Melanoma

Toxic Epidermal Necrolysis-like Reaction With Severe Satellite Cell Necrosis Associated With Nivolumab in a Patient With Ipilimumab Refractory Metastatic Melanoma

Nivolumab is a fully humanized monoclonal antibody to PD-1, which has shown improved overall and progression-free survival. Across studies of nivolumab, grade 3 or 4 rash has been noted in

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Bibliographische Detailangaben
Veröffentlicht in:Journal of immunotherapy (1997) 2016-04, Vol.39 (3), p.149-152
Hauptverfasser: Nayar, Namrata, Briscoe, Karen, Fernandez Penas, Pablo
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Biopsy
Disease Progression
Drug Resistance, Neoplasm
Fatal Outcome
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Ipilimumab
Melanoma - complications
Melanoma - drug therapy
Melanoma - pathology
Middle Aged
Neoplasm Metastasis
Skin - pathology
Steroids - therapeutic use
Stevens-Johnson Syndrome - diagnosis
Stevens-Johnson Syndrome - drug therapy
Stevens-Johnson Syndrome - etiology
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Beschreibung
Zusammenfassung:Nivolumab is a fully humanized monoclonal antibody to PD-1, which has shown improved overall and progression-free survival. Across studies of nivolumab, grade 3 or 4 rash has been noted in
ISSN:1524-9557
1537-4513
DOI:10.1097/CJI.0000000000000112