ANTIBACTERIAL ACTIVITY OF MENTHA PIPERITA AND CITRUS LIMETTA AGAINST PROPIONIBACTERIUM ACNES (ANAEROBIC BACTERIA)

Acne vulgaris, the inflammatory disease of sebaceous follicles of skin with Propioni bacterium acnes (an anaerobic pathogen) play deliberate role in its pathogenesis by inducing certain inflammatory mediators. The aim of present study was to evaluate the antibacterial activity of crude ethanolic extract of Mentha piperata and essential oil of the peel of Citrus limetta (extracted by hydrodistillation process) and control (Tetracycline) against Propioni bacterium acnes (MTCC 1951). Under the technique of Broth Micro dilution method, recommended by CLSI (NCCLS), for MICs as well as IC50 values analyzed. The oil of Citrus limetta (MIC: 2.99, IC50: 1.889) found to be highly active. Mentha piperata shows comparatively low activity (MIC: RANGE, IC50:0.345). The activities were compared with reading of standard tetracycline.