Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia

Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia

Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers...

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Veröffentlicht in:Molecular biology (New York) 2016-05, Vol.50 (3), p.344-352
Hauptverfasser: Orlova, N. N., Lebedev, T. D., Spirin, P. V., Prassolov, V. S.
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Biochemistry
Biomedical and Life Sciences
DNA repair
Human Genetics
Leukemia
Life Sciences
Molecular biology
Reviews
Signal transduction
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Beschreibung
Zusammenfassung:Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893316020187