P13.05 SECOND RADIOTHERAPY TREATMENT IN RECURRENT BRAIN TUMORS

BACKGROUND: Radiotherapy for recurrent irradiated brain tumors is limited by toxicity. The purpose of this study is to determine whether second radiotherapy treatment is beneficial or not for patients with recurrent brain tumors. PATIENTS AND METHODS: In a prospective study, 11 patients who recurred after primary brain tumors, first treated between 2005-2012, were analyzed for second radiotherapy treatment. Tumor histologic types are: glioblastoma multiforme (7), grade 2 astrocytoma (2), grade 3 oligodendroglioma (1) and grade 3 oligoastrocytoma (1). First radiotherapy (RT1) was performed with TD= 50-60Gy, 2Gy/ fraction for 8 patients and TD = 30 GY, 3Gy/ fraction in one patient. DFS (disease free survival) until the recurrence was 5.3-90.6 months. Second radiotherapy treatment (RT2) was associated with surgery and chemotherapy in 8 patients, with surgery or chemotherapy 2 patients; radiotherapy alone was performed in one patient. Karnofsky Index (KI) at RT2 was >70 for 9 patients and