Characterization of the immune response induced by pertussis OMVs-based vaccine

Highlights • Tdap OMVs Bp vaccine induces a mixed Th1/Th2 and Th17 immune response. • Tdap OMVs Bp vaccination induces a robust antibody response with a high IgG2a/IgG1 rate. • Tdap OMVs Bp -raised antibodies partially protect against B. pertussis infection. • B. pertussis was efficiently opsonized...

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Veröffentlicht in:	Vaccine 2016-06, Vol.34 (28), p.3303-3309
Hauptverfasser:	Bottero, D, Gaillard, M.E, Zurita, E, Moreno, G, Martinez, D. Sabater, Bartel, E, Bravo, S, Carriquiriborde, F, Errea, A, Castuma, C, Rumbo, M, Hozbor, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acellular vaccine Allergy and Immunology Animals Antibodies, Bacterial - blood Antigens Bacteria Bordetella pertussis Cells, Cultured Female Humans Immune response Immune Sera - immunology Immunity, Humoral Immunization Infections Interferon-gamma - immunology Interleukin-17 - immunology Interleukin-6 - immunology Mice Mice, Inbred BALB C OMVs Pertussis Vaccine - immunology Phagocytosis Protection RAW 264.7 Cells Spleen - cytology Spleen - immunology Th17 Cells - immunology Vaccines Vaccines, Acellular - immunology Whooping cough Whooping Cough - prevention & control
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Beschreibung
Zusammenfassung:	Highlights • Tdap OMVs Bp vaccine induces a mixed Th1/Th2 and Th17 immune response. • Tdap OMVs Bp vaccination induces a robust antibody response with a high IgG2a/IgG1 rate. • Tdap OMVs Bp -raised antibodies partially protect against B. pertussis infection. • B. pertussis was efficiently opsonized by both Tdap OMVs Bp and wP-induced serum antibodies. • GroEL, OMPc, PTx, PRN and Fim were identified as the main OMVs immunogens.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.04.079