Status of research and development of vaccines for Streptococcus pyogenes

Highlights • There is a clear case for development of vaccines against S. pyogenes given the large disease burden. • The biological feasibility of vaccines against S. pyogenes is well supported. • There are multiple vaccine candidates in clinical and pre-clinical development.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-06, Vol.34 (26), p.2953-2958
Hauptverfasser:	Steer, Andrew C, Carapetis, Jonathan R, Dale, James B, Fraser, John D, Good, Michael F, Guilherme, Luiza, Moreland, Nicole J, Mulholland, E. Kim, Schodel, Florian, Smeesters, Pierre R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens Antigens, Bacterial - immunology Bacteria Bacterial Outer Membrane Proteins - immunology Biomedical Research - trends Cardiovascular disease Cardiovascular diseases Carrier Proteins - immunology Clinical Trials as Topic Developing countries Fatalities Group A Streptococcus Humans Infections LDCs Low income groups Mortality Proteins R&D Research & development Rheumatic fever Sepsis Streptococcal Infections - prevention & control Streptococcal Vaccines - therapeutic use Streptococcus pyogenes Vaccine Vaccines Virulence Factors - immunology
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Beschreibung
Zusammenfassung:	Highlights • There is a clear case for development of vaccines against S. pyogenes given the large disease burden. • The biological feasibility of vaccines against S. pyogenes is well supported. • There are multiple vaccine candidates in clinical and pre-clinical development.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.03.073