Immunohistochemical expression of p63, Ki67 and β-catenin in canine transitional cell carcinoma and polypoid cystitis of the urinary bladder

Transitional cell carcinoma (TCC) is a urinary bladder tumour associated with high mortality in dogs. In this study, we investigated the feasibility of using p63, Ki67 or β‐catenin as a clinical marker for predicting biological behaviour and prognosis in canine TCC. Expression levels of these protei...

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Veröffentlicht in:	Veterinary & comparative oncology 2016-09, Vol.14 (3), p.263-269
Hauptverfasser:	Hanazono, K., Nishimori, T., Fukumoto, S., Kawamura, Y., Endo, Y., Kadosawa, T., Uchide, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Biomarkers, Tumor canine Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - veterinary Cystitis - metabolism Cystitis - veterinary Dog Diseases - metabolism Dogs Immunohistochemistry - veterinary Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Ki67 Neoplasm Invasiveness Neoplasm Metastasis p63 Phosphoproteins - genetics Phosphoproteins - metabolism Trans-Activators - metabolism transitional cell carcinoma Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - veterinary β-catenin
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Zusammenfassung:	Transitional cell carcinoma (TCC) is a urinary bladder tumour associated with high mortality in dogs. In this study, we investigated the feasibility of using p63, Ki67 or β‐catenin as a clinical marker for predicting biological behaviour and prognosis in canine TCC. Expression levels of these proteins in TCC (n = 25), polypoid cystitis (n = 5) and normal urinary bladder (n = 5) were scored after immunohistochemical staining. The staining scores for p63 (P
ISSN:	1476-5810 1476-5829
DOI:	10.1111/vco.12095