Clinical impact and cost-effectiveness of a central line bundle including split-septum and single-use prefilled flushing devices on central line–associated bloodstream infection rates in a pediatric intensive care unit

Highlights • Implementation of a central line bundle program including split-septum and single-use prefilled flushing devices in the pediatric intensive care unit lowered central line–associated bloodstream infection rates. • Implementation of a central line bundle program decreased the daily cost of the patients, mainly by decreasing the antimicro bial and antifungal drug costs by increasing infection-free catheter days. • Decrease in antimicrobial and antifungal drug costs saved one-fifth of the daily cost of hospitalization determined by the health care payer.