Periodic ventilation: consequences for the bodily CO2 stores and gas exchange efficiency

Highlights • Periodic ventilation is intrinsically less efficient for CO2 excretion. • Inefficiency is due to the arrangement of the storage capacities of the compartments. • CO2 transport becomes more prone to perfusion and diffusion limitation. • Inefficiency increase with the apnoeic duration and...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2016-09, Vol.231, p.63-74
Hauptverfasser:	Malte, Christian Lind, Malte, Hans, Wang, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Apnea - metabolism Breath-holding Carbon Dioxide - metabolism CO2 transport Diving Humans Linear Models Lung - metabolism Mathematical model Medical Education Models, Biological Nonlinear Dynamics Periodic ventilation Periodicity Pulmonary Gas Exchange - physiology Pulmonary/Respiratory Time Factors Ventilation/perfusion ([formula omitted]) matching
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Zusammenfassung:	Highlights • Periodic ventilation is intrinsically less efficient for CO2 excretion. • Inefficiency is due to the arrangement of the storage capacities of the compartments. • CO2 transport becomes more prone to perfusion and diffusion limitation. • Inefficiency increase with the apnoeic duration and relative time spent apnoeic. • Inefficiency can be compensated by temporal matching of blood flow to ventilation.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2016.05.011