Theoretical Basis for and Improvement of Daugirdas' Second Generation Formula for Single-Pool Kt/V
Purpose An empirically-derived equation to estimate hemodialysis treatment variable-volume single-pool Kt/V, where Kt/V = −ln(R-GFAC × t) + (4−3.5 × R) × UFV/W, was published in 1993 (1) and quickly became a standard tool for the estimation of dialysis dose. We aim to find a theoretical basis for th...
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Veröffentlicht in: | International journal of artificial organs 2015-12, Vol.38 (12), p.632-637 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Purpose
An empirically-derived equation to estimate hemodialysis treatment variable-volume single-pool Kt/V, where Kt/V = −ln(R-GFAC × t) + (4−3.5 × R) × UFV/W, was published in 1993 (1) and quickly became a standard tool for the estimation of dialysis dose. We aim to find a theoretical basis for this equation.
Methods
A mathematical derivation is used to find the connection between Kt/V and modeled urea concentrations.
Results
There is a theoretical basis for the empirical structure of the estimating equation, but the estimation of the effect of ultrafiltration on Kt/V can be improved. Finally, we show that the accuracy of the formula may be suboptimal for some extreme dialysis schedules and propose a new equation that is more robust across atypical dialysis prescriptions.
Conclusions
The currently used Kt/V estimating equation has a sound theoretical basis and an improved version is proposed that can maintain accuracy with a broader range of fluid removal. |
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ISSN: | 0391-3988 1724-6040 |
DOI: | 10.5301/ijao.5000456 |