DNA Gridiron Nanostructures Based on Four-Arm Junctions

Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments....

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Veröffentlicht in:Science 2013-03, Vol.339 (6126), p.1412-1415
Hauptverfasser: Han, Dongran, Pal, Suchetan, Yang, Yang, Jiang, Shuoxing, Nangreave, Jeanette, Liu, Yan, Yan, Hao
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Sprache:eng
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Zusammenfassung:Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1232252