Frontispiece: Chemoenzymatic Synthesis of Pleiogenone A: An Antiproliferative Trihydroxyalkylcyclohexenone Isolated from Pleiogynium timorense

Natural Products Pleiogenone A, which has been isolated from Pleiogynium timorense, has been synthesized for the first time. The synthesis confirms the previously reported structure as well as the absolute configuration. The route started with the enzymatic dihydroxylation of inexpensive and readily available benzoic acid by R. eutrophus B9. For more details, see the Full Paper by T. Hudlicky et al. on page 6180 ff. Jordan Froese and Dennis Ceci, both at Brock University, are acknowledged for the design of the Frontispiece.