Poly(ethylene) glycols and mechanochemistry for the preparation of bioactive 3,5-disubstituted hydantoins

Mechanochemistry was effective for the preparation of 3,5-disubstituted hydantoins from -amino methyl esters, using either 1,1-carbonyldiimidazole (CDI) or alkyl isocyanates. The preparation of the antimicrobial additives, 3-allyl-5,5-dimethyl hydantoin (ADMH) and 1-chloro-3-ethyl-5,5-dimethyl hydantoin (CEDMH) were performed by grinding. A chlorination reaction, never described before by mechanochemistry was achieved by Ca(ClO) 2 , while the preparation of the bioactive anticonvulsant marketed drug ethotoin was achieved by a novel approach based on poly(ethylene) glycol (PEGs) assisted grinding. Mechanochemistry was effective for the preparation of 3,5-disubstituted hydantoins from -amino methyl esters, using either 1,1-carbonyldiimidazole (CDI) or alkyl isocyanates.