A Device for Albumin and Cytosol Detoxication

A Device for Albumin and Cytosol Detoxication

A new detoxication method based the Bioartificial Liver apparatus and the use of human serum albumin (HSA) and porcine hepatocyte cytosol (PHC) is described. The method is based on the interaction of HSA and PHC with the patient’s blood through a semi-permeable membrane. The apparatus consists of a...

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Veröffentlicht in:Biomedical engineering 2014-09, Vol.48 (3), p.126-129
Hauptverfasser: Ryabinin, V. E., Polevschikova, E. E., Suprun, V. I., Egorov, A. P.
Format: Artikel
Sprache:eng
Schlagworte:
Albumin
Artificial organs
Biochemical markers
Biomarkers
Biomaterials
Biomedical Engineering and Bioengineering
Bioreactors
Blood
Cholestasis
Cytolysis
Cytosol
Devices
Engineering
Human serum albumin
Intoxication
Liver
Membranes
Oxygenation
Patient safety
Patients
Serum albumin
Side effects
Thermoregulation
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Zusammenfassung:A new detoxication method based the Bioartificial Liver apparatus and the use of human serum albumin (HSA) and porcine hepatocyte cytosol (PHC) is described. The method is based on the interaction of HSA and PHC with the patient’s blood through a semi-permeable membrane. The apparatus consists of a bioreactor, hemodialyzer, and blood line as well as thermoregulation, oxygenation, and procedure safety systems. The PHC and HSA dialyzing media were tested using the Bioartificial Liver apparatus. They appeared to be highly effective and capable of reducing biochemical markers of cytolysis, cholestasis, and endogenous intoxication in patients without any adverse side effects. Thus, the method can be recommended for further clinical tests and introduction into intensive care practice.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-014-9435-0