Sulfination of alcohols with sodium sulfinates promoted by BF sub(3).OEt sub(2): an unexpected access

Sulfination of alcohols with sodium sulfinates promoted by BF sub(3).OEt sub(2): an unexpected access

A BF sub(3).OEt sub(2)-promo ted direct substitution of various alcohols with sodium sulfinates affording sulfinates under mild conditions has been developed. Further reaction of the hydroxysteroids achieves the highly complex sulfinates in good yields, which are two potential pharmacophores routine...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2016-03, Vol.18 (7), p.1874-1879
Hauptverfasser: Huang, Mingming, Hu, Liangzhen, Shen, Hang, Liu, Qing, Hussain, Muhammad Ijaz, Pan, Jing, Xiong, Yan
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Drugs
Hydroxysteroids
Pharmacology
Sodium
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Zusammenfassung:A BF sub(3).OEt sub(2)-promo ted direct substitution of various alcohols with sodium sulfinates affording sulfinates under mild conditions has been developed. Further reaction of the hydroxysteroids achieves the highly complex sulfinates in good yields, which are two potential pharmacophores routinely encountered in drug discovery.
ISSN:1463-9262
1463-9270
DOI:10.1039/c5gc02846a