Measurement and Correlation of Solubility of Nitrendipine in Supercritical Carbon Dioxide With and Without Ethanol Cosolvent

The solubilities of nitrendipine in supercritical carbon dioxide (ScCO 2 ) and in the presence of 1, 3, 5, and 7 mol.% ethanol, were measured at 308, 318, and 328 K over a pressure range of 8–20 MPa. The experimental results reveal that the solubility increased with increasing pressure; the effect o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of solution chemistry 2015-01, Vol.44 (1), p.1-15
Hauptverfasser:	Zhan, Shiping, Cui, Liyun, Zhao, Qicheng, Chen, Li, Wang, Jingchang, Chen, Shuhua, Ding, Shiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon dioxide Chemistry Chemistry and Materials Science Condensed Matter Physics Correlation Correlation analysis Ethanol Ethyl alcohol Geochemistry Industrial Chemistry/Chemical Engineering Inorganic Chemistry Mathematical models Oceanography Physical Chemistry Solubility Wedges
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The solubilities of nitrendipine in supercritical carbon dioxide (ScCO 2 ) and in the presence of 1, 3, 5, and 7 mol.% ethanol, were measured at 308, 318, and 328 K over a pressure range of 8–20 MPa. The experimental results reveal that the solubility increased with increasing pressure; the effect of temperature was more complex with or without cosolvent. The solubilities obtained in pure ScCO 2 are relatively low, and they were successfully correlated by two semi-empirical models (Chrastil, Sung and Shim (SS) models). The solubility is increased significantly with ethanol as cosolvent, and these data were also correlated well using the modified Méndez-Santiago and Teja (M-ST) models.
ISSN:	0095-9782 1572-8927
DOI:	10.1007/s10953-014-0262-4