Synthesis of Some Novel Benzoxazolinonylcarboxamides as Potential Anti-Inflammatory Agents

The synthesis of new 2(3H)-benzoxazolinonylcarboxamides starting from 2-amino-4,6-dimethylpyridine and 2(3H)-benzoxazolone which were designed as anti-inflammatory agents is described. These derivatives were synthesised from 2(3H)-(benzoxazolinon-6-yl)carboxylic acids, which were obtained by Friedel-Crafts acylation of 2(3H)-benzoxazolone derivatives with oxalyl chloride and acetylchloride in the presence of the AlCl3-DMF complex. The constitution of the products was supported by elemental analysis IR and 1H NMR spectral data.