Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic co...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-04, Vol.28 (16), p.3102-3110
Hauptverfasser: Cai, Pingqiang, Layani, Michael, Leow, Wan Ru, Amini, Shahrouz, Liu, Zhiyuan, Qi, Dianpeng, Hu, Benhui, Wu, Yun-Long, Miserez, Ali, Magdassi, Shlomo, Chen, Xiaodong
Format: Artikel
Sprache:eng
Schlagworte:
3D printing
bio-inspired materials
Biomimetic Materials - chemistry
Cell Movement
collective cell migration
Coupling
Electrochemical machining
Epithelial Cells - cytology
Extracellular Matrix - chemistry
Hydrogels
Hydrogels - chemistry
mechanotaxis
Microstructure
Migration
Molds
Platforms
Printing, Three-Dimensional
Stiffness
stiffness gradient
Traction - methods
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Zusammenfassung:A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic coupling of epithelial migration with the stiffness of the extracellular matrix (ECM) is found to be independent of the interfacial compositional and topographical cues.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201505300