Geant4.10 simulation of geometric model for metaphase chromosome

Geant4.10 simulation of geometric model for metaphase chromosome

In this paper, a geometric model of metaphase chromosome is explained. The model is constructed according to the packing ratio and dimension of the structure from nucleosome up to chromosome. A B-DNA base pair is used to construct 200 base pairs of nucleosomes. Each chromatin fiber loop, which is th...

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Veröffentlicht in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2016-04, Vol.372, p.7-13
Hauptverfasser: Rafat-Motavalli, L., Miri-Hakimabad, H., Bakhtiyari, E.
Format: Artikel
Sprache:eng
Schlagworte:
B-DNA
Chromatin fiber loop
Chromosome
Chromosomes
Computer simulation
Construction
Deoxyribonucleic acid
Geant4.10
Human
Mathematical models
Monte Carlo methods
Relative length
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Zusammenfassung:In this paper, a geometric model of metaphase chromosome is explained. The model is constructed according to the packing ratio and dimension of the structure from nucleosome up to chromosome. A B-DNA base pair is used to construct 200 base pairs of nucleosomes. Each chromatin fiber loop, which is the unit of repeat, has 49,200bp. This geometry is entered in Geant4.10 Monte Carlo simulation toolkit and can be extended to the whole metaphase chromosomes and any application in which a DNA geometrical model is needed. The chromosome base pairs, chromosome length, and relative length of chromosomes are calculated. The calculated relative length is compared to the relative length of human chromosomes.
ISSN:0168-583X
1872-9584
DOI:10.1016/j.nimb.2016.01.028