Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

An innovative microneedle (MN)‐based cell therapy is developed for glucose‐responsive regulation of the insulin secretion from exogenous pancreatic β‐cells without implantation. One MN patch can quickly reduce the blood‐sugar levels (BGLs) of chemically induced type‐1 diabetic mice and stabilize BGL...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-04, Vol.28 (16), p.3115-3121
Hauptverfasser:	Ye, Yanqi, Yu, Jicheng, Wang, Chao, Nguyen, Nhu-Y, Walker, Glenn M., Buse, John B., Gu, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplifiers Animals Blood Glucose - analysis Blood Glucose - metabolism Control diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology drug delivery Implantation Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Mice microneedles Needles pancreatic cells physiological signals Secretions Therapy Time Factors
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Beschreibung
Zusammenfassung:	An innovative microneedle (MN)‐based cell therapy is developed for glucose‐responsive regulation of the insulin secretion from exogenous pancreatic β‐cells without implantation. One MN patch can quickly reduce the blood‐sugar levels (BGLs) of chemically induced type‐1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201506025