Risk Factors of Lymph Nodes Metastases by Endometrial Cancer: A Retrospective One-center Study

We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC). The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014. Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS). Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases.