Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2016-08, Vol.41 (8), p.650-653
Hauptverfasser: Ahdash, Zainab, Pyle, Euan, Politis, Argyris
Format: Artikel
Sprache:eng
Schlagworte:
conformational states
hybrid approaches
integrative modelling
mass spectrometry
Mass Spectrometry - methods
protein complexes
Protein Conformation
Proteins - chemistry
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Zusammenfassung:A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2016.04.008