Release of levetiracetam from extended-release tablets that appear intact in patient stool

[Display omitted] •Release of levetiracetam from extended-release tablets that appear intact in patient stool.•A generic levetiracetam ER 500mg tablet from Lupin produced tablet remnants in patient stool.•Other levetiracetam ER generics do not yield tablet remnants in patient stool.•The Lupin generi...

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Veröffentlicht in:	Seizure (London, England) England), 2016-08, Vol.40, p.7-9
Hauptverfasser:	Vaithianathan, Soundarya, Ting, Tricia Y, Jiang, Wenlei, Polli, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - administration & dosage Anticonvulsants - pharmacokinetics Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacokinetics Extended-release Feces Generic Humans Levetiracetam Neurology Piracetam - administration & dosage Piracetam - analogs & derivatives Piracetam - pharmacokinetics Remnant Stool Tablet Tablets - administration & dosage Tablets - pharmacokinetics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	[Display omitted] •Release of levetiracetam from extended-release tablets that appear intact in patient stool.•A generic levetiracetam ER 500mg tablet from Lupin produced tablet remnants in patient stool.•Other levetiracetam ER generics do not yield tablet remnants in patient stool.•The Lupin generic released all drug.•Patients should be aware that some generic ER tablets may appear in the stool.
ISSN:	1059-1311 1532-2688
DOI:	10.1016/j.seizure.2016.05.011