Oxaliplatin-induced acute thrombocytopenia

Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are n...

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Veröffentlicht in:	Journal of cancer research and therapeutics 2016-04, Vol.12 (2), p.509-514
Hauptverfasser:	Erdem, Gokmen, Dogan, Mutlu, Demirci, Nebi, Zengin, Nurullah
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Anemia Antineoplastic Agents - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Back pain Blood platelets Care and treatment Chemotherapy Complications and side effects Development and progression Drug dosages Gastrointestinal Neoplasms - complications Gastrointestinal Neoplasms - drug therapy Humans Hypertension Immunoglobulins Lymphatic system Metastasis Organoplatinum Compounds - adverse effects Oxaliplatin Patients Thrombocytopenia Thrombocytopenia - diagnosis Thrombocytopenia - etiology Thrombocytopenia - therapy
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Zusammenfassung:	Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are neurotoxicity (peripheral neuropathy), myelosuppression with moderate thrombocytopenia and gastrointestinal toxicity (diarrhea). Thrombocytopenia might be related to myelosuppression and/or drug-induced immune thrombocytopenia (DIIT). In here, oxaliplatin-induced thrombocytopenia is discussed with review of the literature.
ISSN:	0973-1482 1998-4138
DOI:	10.4103/0973-1482.154056