Superfluorinated PEI Derivative Coupled with (99m) Tc for ASGPR Targeted (19) F MRI/SPECT/PA Tri-Modality Imaging

Superfluorinated PEI Derivative Coupled with (99m) Tc for ASGPR Targeted (19) F MRI/SPECT/PA Tri-Modality Imaging

Fluorinated polyethylenimine derivative labeled with radionuclide (99m) Tc is developed as a (19) F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for (19) F MRI/SPECT/PA imaging and has the...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-07, Vol.28 (28), p.5898-5906
Hauptverfasser: Guo, Zhide, Gao, Mengna, Song, Manli, Li, Yesen, Zhang, Deliang, Xu, Duo, You, Linyi, Wang, Liangliang, Zhuang, Rongqiang, Su, Xinhui, Liu, Ting, Du, Jin, Zhang, Xianzhong
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Sprache:eng
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Zusammenfassung:Fluorinated polyethylenimine derivative labeled with radionuclide (99m) Tc is developed as a (19) F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for (19) F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.
ISSN:1521-4095
DOI:10.1002/adma.201601064