T Cell Division and Death Are Segregated by Mutation of TCRβ Chain Constant Domains
We have studied the role of the T cell receptor (TCR) β chain transmembrane and cytoplasmic domains (βTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and βTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing a...
Gespeichert in:
Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2004-10, Vol.21 (4), p.515-526 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We have studied the role of the T cell receptor (TCR) β chain transmembrane and cytoplasmic domains (βTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and βTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-κB. This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These β chain domains are involved in discriminating cell division and apoptosis. |
---|---|
ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/j.immuni.2004.08.014 |