new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra

A novel anti-HIV alkaloid, drymaritin (1), and a new C-glycoside flavonoid, diandraflavone (2), along with eight known compounds, torosaflavone A, isovitexin, spinasterol beta-d-glycoside, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, cis-p-coumarate, methyl 5-hydroxy-4-oxopentanoate, and glycerol-a...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-07, Vol.67 (7), p.1175-1177
Hauptverfasser:	Hsieh, P.W, Chang, F.R, Lee, K.H, Hwang, T.L, Chang, S.M, Wu, Y.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Biological and medical sciences Carbolines - chemistry Carbolines - isolation & purification Carbolines - pharmacology Caryophyllaceae - chemistry Drymaria diandra Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Humans Inhibitory Concentration 50 Lymphocytes - drug effects Medical sciences Medicine, Traditional Neutrophils - drug effects Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Taiwan
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Zusammenfassung:	A novel anti-HIV alkaloid, drymaritin (1), and a new C-glycoside flavonoid, diandraflavone (2), along with eight known compounds, torosaflavone A, isovitexin, spinasterol beta-d-glycoside, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, cis-p-coumarate, methyl 5-hydroxy-4-oxopentanoate, and glycerol-alpha-lignocerate, were isolated from Drymaria diandra. Drymaritin (1) exhibited anti-HIV effects in H9 lymphocytes with an EC(50) value of 0.699 microg/mL and a TI of 20.6. Compound 2 showed significantly selective inhibition on superoxide anion generation from human neutrophils stimulated by fMLP/CB with an IC(50) value of 10.0 microg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0400196