A comparison of salivary testosterone measurement using immunoassays and tandem mass spectrometry

A comparison of salivary testosterone measurement using immunoassays and tandem mass spectrometry

Highlights • EIAs from DRG International most accurately measured testosterone. • DRG EIAs showed the least biased estimates in higher ranges of testosterone. • EIAs overestimated women's testosterone when testosterone was higher. • Testosterone EIAs had less linear agreement with LC-MS/MS comp...

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Veröffentlicht in:Psychoneuroendocrinology 2016-09, Vol.71, p.180-188
Hauptverfasser: Welker, Keith M, Lassetter, Bethany, Brandes, Cassandra, Prasad, Smrithi, Koop, Dennis R, Mehta, Pranjal H
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Chromatography, Liquid - methods
Endocrinology & Metabolism
Female
Humans
Immunoassays
Immunoenzyme Techniques - methods
Liquid chromatography
Male
Mass spectrometry
Measurement
Psychiatry
Reproducibility of Results
Saliva - chemistry
Salivary testosterone
Sensitivity and Specificity
Tandem Mass Spectrometry - methods
Testosterone - analysis
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Beschreibung
Zusammenfassung:Highlights • EIAs from DRG International most accurately measured testosterone. • DRG EIAs showed the least biased estimates in higher ranges of testosterone. • EIAs overestimated women's testosterone when testosterone was higher. • Testosterone EIAs had less linear agreement with LC-MS/MS compared to cortisol EIAs
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.05.022