Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients
Abstract Objective To investigate effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients. Methods A retrospective analysis was performed in 109 (including 3 outpatients) CSDH patients of Northern Jiangsu People's Hospital from April，2014 to Oct...
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| Veröffentlicht in: | World neurosurgery 2016-07, Vol.91, p.23-28 |
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| creator | Min, Xu, MD Pin, Chen, MD Xun, Zhu, MM Cun-zu, Wang, MD, PhD Xue-qiang, Shi Bo, Yu, MD |
| description | Abstract Objective To investigate effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients. Methods A retrospective analysis was performed in 109 (including 3 outpatients) CSDH patients of Northern Jiangsu People's Hospital from April，2014 to Oct 2015. Patients’ gender, age, Glasgow Coma Scale (GCS), symptoms, history of antiplatelet or anticoagulant, hematoma location, volume of hematoma, operation methods, application of atorvastatin and its duration were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Results Seven conservative patients received atorvastatin for 1-6 months (3.57 ± 1.72 months). The volume of hematomas were significantly reduced from 20.83 ± 4.49 ml to 11.40 ± 4.46 ml (p |
| doi_str_mv | 10.1016/j.wneu.2016.03.067 |
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Methods A retrospective analysis was performed in 109 (including 3 outpatients) CSDH patients of Northern Jiangsu People's Hospital from April，2014 to Oct 2015. Patients’ gender, age, Glasgow Coma Scale (GCS), symptoms, history of antiplatelet or anticoagulant, hematoma location, volume of hematoma, operation methods, application of atorvastatin and its duration were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Results Seven conservative patients received atorvastatin for 1-6 months (3.57 ± 1.72 months). The volume of hematomas were significantly reduced from 20.83 ± 4.49 ml to 11.40 ± 4.46 ml (p<0.05) after 1 month’s atorvastatin treatment. Hematomas were disappeared after 6 months in all the 7 patients. In the surgical patients, gender ( p =0.797), age ( p =0.063), GCS ( p =0.216), history of antiplatelet or anticoagulant ( p =0.350), volume of hematoma after admission ( p =0.896), location ( p =0.282), operation methods ( p =0.832) were shown non-significantly associated with follow-up groups. However, the follow-up results indicated atorvastatin was significantly associated with the reduced volume of hematomas in surgical patients ( p =0.045). Conclusion Atorvastatin is preliminary proved to be safe and effective on chronic subdural hematomas in both conservative and surgical patients, which can provide a drug treatment strategy for neurosurgeons.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2016.03.067</identifier><identifier>PMID: 27044372</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Atorvastatin ; Atorvastatin Calcium - administration & dosage ; Atorvastatin Calcium - pharmacology ; Chronic subdural hematoma ; Conservative ; Female ; Hematoma, Subdural, Chronic - drug therapy ; Hematoma, Subdural, Chronic - surgery ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Male ; Middle Aged ; Neurosurgery ; Outcome Assessment (Health Care) ; Prognosis ; Surgical</subject><ispartof>World neurosurgery, 2016-07, Vol.91, p.23-28</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-ea061bcac409802b6c280f734ec1f8aea7e8a99d00e16108af30b5a4c9037a4a3</citedby><cites>FETCH-LOGICAL-c477t-ea061bcac409802b6c280f734ec1f8aea7e8a99d00e16108af30b5a4c9037a4a3</cites><orcidid>0000-0001-7716-2380</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2016.03.067$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27044372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Min, Xu, MD</creatorcontrib><creatorcontrib>Pin, Chen, MD</creatorcontrib><creatorcontrib>Xun, Zhu, MM</creatorcontrib><creatorcontrib>Cun-zu, Wang, MD, PhD</creatorcontrib><creatorcontrib>Xue-qiang, Shi</creatorcontrib><creatorcontrib>Bo, Yu, MD</creatorcontrib><title>Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Abstract Objective To investigate effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients. Methods A retrospective analysis was performed in 109 (including 3 outpatients) CSDH patients of Northern Jiangsu People's Hospital from April，2014 to Oct 2015. Patients’ gender, age, Glasgow Coma Scale (GCS), symptoms, history of antiplatelet or anticoagulant, hematoma location, volume of hematoma, operation methods, application of atorvastatin and its duration were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Results Seven conservative patients received atorvastatin for 1-6 months (3.57 ± 1.72 months). The volume of hematomas were significantly reduced from 20.83 ± 4.49 ml to 11.40 ± 4.46 ml (p<0.05) after 1 month’s atorvastatin treatment. Hematomas were disappeared after 6 months in all the 7 patients. In the surgical patients, gender ( p =0.797), age ( p =0.063), GCS ( p =0.216), history of antiplatelet or anticoagulant ( p =0.350), volume of hematoma after admission ( p =0.896), location ( p =0.282), operation methods ( p =0.832) were shown non-significantly associated with follow-up groups. However, the follow-up results indicated atorvastatin was significantly associated with the reduced volume of hematomas in surgical patients ( p =0.045). Conclusion Atorvastatin is preliminary proved to be safe and effective on chronic subdural hematomas in both conservative and surgical patients, which can provide a drug treatment strategy for neurosurgeons.</description><subject>Aged</subject><subject>Atorvastatin</subject><subject>Atorvastatin Calcium - administration & dosage</subject><subject>Atorvastatin Calcium - pharmacology</subject><subject>Chronic subdural hematoma</subject><subject>Conservative</subject><subject>Female</subject><subject>Hematoma, Subdural, Chronic - drug therapy</subject><subject>Hematoma, Subdural, Chronic - surgery</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurosurgery</subject><subject>Outcome Assessment (Health Care)</subject><subject>Prognosis</subject><subject>Surgical</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVpaUKSL5BD8bGXdUeWVpKhFEpI_0CghzRnMZbHXW1taSvZW_LtK7NpDj10LjNo3nug3zB2zaHmwNW7ff070FI3Za5B1KD0C3bOjTYbo1X78nnewhm7ynkPpQSXRovX7KzRIKXQzTnb3Q4DuTlXcahwjumIecbZhyqGysWQqbzM_kgVhr7KS_rhHY7VnAjnicLJ53YpBu_KuuuXVNY7mkrWhFXJORT7KrxkrwYcM1099Qv28On2-82Xzd23z19vPt5tnNR63hCC4p1DJ6E10HTKNQYGLSQ5Phgk1GSwbXsA4oqDwUFAt0XpWhAaJYoL9vaUe0jx10J5tpPPjsYRA8UlW25gq5XhQhdpc5K6FHNONNhD8hOmR8vBrpDt3q6Q7QrZgrAFcjG9ecpfuon6Z8tfpEXw_iSg8sujp2SzKwQc9T4V0raP_v_5H_6xu9GHlfpPeqS8j0sKhZ_lNjcW7P165vXKXAFIo7j4AwI-pJo</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Min, Xu, MD</creator><creator>Pin, Chen, MD</creator><creator>Xun, Zhu, MM</creator><creator>Cun-zu, Wang, MD, PhD</creator><creator>Xue-qiang, Shi</creator><creator>Bo, Yu, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7716-2380</orcidid></search><sort><creationdate>20160701</creationdate><title>Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients</title><author>Min, Xu, MD ; Pin, Chen, MD ; Xun, Zhu, MM ; Cun-zu, Wang, MD, PhD ; Xue-qiang, Shi ; Bo, Yu, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ea061bcac409802b6c280f734ec1f8aea7e8a99d00e16108af30b5a4c9037a4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Atorvastatin</topic><topic>Atorvastatin Calcium - administration & dosage</topic><topic>Atorvastatin Calcium - pharmacology</topic><topic>Chronic subdural hematoma</topic><topic>Conservative</topic><topic>Female</topic><topic>Hematoma, Subdural, Chronic - drug therapy</topic><topic>Hematoma, Subdural, Chronic - surgery</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurosurgery</topic><topic>Outcome Assessment (Health Care)</topic><topic>Prognosis</topic><topic>Surgical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Min, Xu, MD</creatorcontrib><creatorcontrib>Pin, Chen, MD</creatorcontrib><creatorcontrib>Xun, Zhu, MM</creatorcontrib><creatorcontrib>Cun-zu, Wang, MD, PhD</creatorcontrib><creatorcontrib>Xue-qiang, Shi</creatorcontrib><creatorcontrib>Bo, Yu, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Min, Xu, MD</au><au>Pin, Chen, MD</au><au>Xun, Zhu, MM</au><au>Cun-zu, Wang, MD, PhD</au><au>Xue-qiang, Shi</au><au>Bo, Yu, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>91</volume><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Abstract Objective To investigate effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients. Methods A retrospective analysis was performed in 109 (including 3 outpatients) CSDH patients of Northern Jiangsu People's Hospital from April，2014 to Oct 2015. Patients’ gender, age, Glasgow Coma Scale (GCS), symptoms, history of antiplatelet or anticoagulant, hematoma location, volume of hematoma, operation methods, application of atorvastatin and its duration were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Results Seven conservative patients received atorvastatin for 1-6 months (3.57 ± 1.72 months). The volume of hematomas were significantly reduced from 20.83 ± 4.49 ml to 11.40 ± 4.46 ml (p<0.05) after 1 month’s atorvastatin treatment. Hematomas were disappeared after 6 months in all the 7 patients. In the surgical patients, gender ( p =0.797), age ( p =0.063), GCS ( p =0.216), history of antiplatelet or anticoagulant ( p =0.350), volume of hematoma after admission ( p =0.896), location ( p =0.282), operation methods ( p =0.832) were shown non-significantly associated with follow-up groups. However, the follow-up results indicated atorvastatin was significantly associated with the reduced volume of hematomas in surgical patients ( p =0.045). Conclusion Atorvastatin is preliminary proved to be safe and effective on chronic subdural hematomas in both conservative and surgical patients, which can provide a drug treatment strategy for neurosurgeons.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27044372</pmid><doi>10.1016/j.wneu.2016.03.067</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7716-2380</orcidid></addata></record> |
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| subjects | Aged Atorvastatin Atorvastatin Calcium - administration & dosage Atorvastatin Calcium - pharmacology Chronic subdural hematoma Conservative Female Hematoma, Subdural, Chronic - drug therapy Hematoma, Subdural, Chronic - surgery Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Middle Aged Neurosurgery Outcome Assessment (Health Care) Prognosis Surgical |
| title | Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients |
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