Statistical detection of nanoparticles in cells by darkfield microscopy

Statistical detection of nanoparticles in cells by darkfield microscopy

Highlights • Use of nanoparticles as contrast agents for medical diagnosis and therapy. • Innovative method to detect nanoparticle presence in eukaryote cells is proposed. • The method is based on enhancement of nanoparticle contrast. • Contrast is enhanced by darkfield micro-spectroscopy technique...

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Veröffentlicht in:Physica medica 2016-07, Vol.32 (7), p.938-943
Hauptverfasser: Gnerucci, Alessio, Romano, Giovanni, Ratto, Fulvio, Centi, Sonia, Baccini, Michela, Santosuosso, Ugo, Pini, Roberto, Fusi, Franco
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies - chemistry
Antibodies - immunology
Biological Transport
CA-125 Antigen - immunology
Darkfield microscopy
Darkness
Gold - chemistry
Gold nanoparticles
HeLa Cells
Humans
Image analysis
Intracellular Membranes - metabolism
Membrane Proteins - immunology
Microscopy - methods
Nanoparticles - chemistry
Nanoparticles - metabolism
Polyethylene Glycols - chemistry
Radiology
Statistical test
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Beschreibung
Zusammenfassung:Highlights • Use of nanoparticles as contrast agents for medical diagnosis and therapy. • Innovative method to detect nanoparticle presence in eukaryote cells is proposed. • The method is based on enhancement of nanoparticle contrast. • Contrast is enhanced by darkfield micro-spectroscopy technique and image analysis. • Statistical tests are applied to quantify the sensitivity of the detection method.
ISSN:1120-1797
1724-191X
DOI:10.1016/j.ejmp.2016.06.007