Dengue encephalitis-associated immunopathology in the mouse model: implications for vaccine developers and antigens inducer of cellular immune response

Highlights • Cell-mediated immunity has a protective role in mouse model of Dengue encephalitis. • There is immunopathology associated to the mouse model of Dengue encephalitis. • Dengue intracranial challenge induces immune cell recruitment within the brain.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-08, Vol.176, p.51-56
Hauptverfasser:	Marcos, Ernesto, Lazo, Laura, Gil, Lázaro, Izquierdo, Alienys, Suzarte, Edith, Valdés, Iris, Blanco, Aracelys, Ancizar, Julio, Alba, José Suárez, Pérez, Yusleydis de la C, Cobas, Karen, Romero, Yaremis, Guillén, Gerardo, Guzmán, María G, Hermida, Lisset
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal model Animals Cells, Cultured Cercopithecus aethiops Cyclophosphamide - therapeutic use Dengue Dengue - immunology Dengue Vaccines - immunology Dengue Virus - immunology Disease Models, Animal Encephalitis Encephalitis - immunology Female Humans Immunity, Cellular Immunocompetence Immunosuppressive Agents - therapeutic use Mice Mice, Inbred BALB C Mouse Vaccine Vero Cells Viral Load
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Beschreibung
Zusammenfassung:	Highlights • Cell-mediated immunity has a protective role in mouse model of Dengue encephalitis. • There is immunopathology associated to the mouse model of Dengue encephalitis. • Dengue intracranial challenge induces immune cell recruitment within the brain.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.05.014