Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development
Highlights • Glucocorticoid (GC) exposure in early placentation induces preeclampsia (PE) in rats. • GC inhibits trophoblast development both in vivo and in vitro. • GC exposure leads to rat PE partially via inhibiting trophoblast invasion and EMT. • GC receptor and ERK are involved in the inhibitio...
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| Veröffentlicht in: | General and comparative endocrinology 2016-01, Vol.225, p.61-70 |
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| container_title | General and comparative endocrinology |
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| creator | Zhang, Dongxin Liu, Haojing Zeng, Ji Miao, Xili Huang, Wei Chen, Hongxiang Huang, Yinping Li, Yongsheng Ye, Duyun |
| description | Highlights • Glucocorticoid (GC) exposure in early placentation induces preeclampsia (PE) in rats. • GC inhibits trophoblast development both in vivo and in vitro. • GC exposure leads to rat PE partially via inhibiting trophoblast invasion and EMT. • GC receptor and ERK are involved in the inhibition of GC on trophoblast development. |
| doi_str_mv | 10.1016/j.ygcen.2015.09.019 |
| format | Article |
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Liu, Haojing ; Zeng, Ji ; Miao, Xili ; Huang, Wei ; Chen, Hongxiang ; Huang, Yinping ; Li, Yongsheng ; Ye, Duyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-fd9816f398d633644e43571ad6a7026774cb765ef2511007ada1fc8c7efd1dd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Dexamethasone - pharmacology</topic><topic>Down-Regulation - drug effects</topic><topic>Endocrinology & Metabolism</topic><topic>Epithelial–mesenchymal transition</topic><topic>Female</topic><topic>Glucocorticoid</topic><topic>Glucocorticoids - pharmacology</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</topic><topic>Male</topic><topic>Oxidative Stress - drug effects</topic><topic>Placenta - drug effects</topic><topic>Placenta - metabolism</topic><topic>Placenta - pathology</topic><topic>Placentation</topic><topic>Placentation - drug effects</topic><topic>Pre-Eclampsia - chemically induced</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Pre-Eclampsia - pathology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Trophoblast development</topic><topic>Trophoblasts - drug effects</topic><topic>Trophoblasts - metabolism</topic><topic>Trophoblasts - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dongxin</creatorcontrib><creatorcontrib>Liu, Haojing</creatorcontrib><creatorcontrib>Zeng, Ji</creatorcontrib><creatorcontrib>Miao, Xili</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Chen, Hongxiang</creatorcontrib><creatorcontrib>Huang, Yinping</creatorcontrib><creatorcontrib>Li, Yongsheng</creatorcontrib><creatorcontrib>Ye, Duyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dongxin</au><au>Liu, Haojing</au><au>Zeng, Ji</au><au>Miao, Xili</au><au>Huang, Wei</au><au>Chen, Hongxiang</au><au>Huang, Yinping</au><au>Li, Yongsheng</au><au>Ye, Duyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>225</volume><spage>61</spage><epage>70</epage><pages>61-70</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Highlights • Glucocorticoid (GC) exposure in early placentation induces preeclampsia (PE) in rats. • GC inhibits trophoblast development both in vivo and in vitro. • GC exposure leads to rat PE partially via inhibiting trophoblast invasion and EMT. • GC receptor and ERK are involved in the inhibition of GC on trophoblast development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26407501</pmid><doi>10.1016/j.ygcen.2015.09.019</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Dexamethasone - pharmacology Down-Regulation - drug effects Endocrinology & Metabolism Epithelial–mesenchymal transition Female Glucocorticoid Glucocorticoids - pharmacology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Male Oxidative Stress - drug effects Placenta - drug effects Placenta - metabolism Placenta - pathology Placentation Placentation - drug effects Pre-Eclampsia - chemically induced Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Preeclampsia Pregnancy Rats Trophoblast development Trophoblasts - drug effects Trophoblasts - metabolism Trophoblasts - pathology |
| title | Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development |
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